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Index > Protein center > Cbr1(Gene name) > Rat
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  • Cbr1 (Gene name),
  • Carbonyl reductase [NADPH] 1 (Protein name ),  CBR1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Cbr1(Cbr);
    Protein name:
    Carbonyl reductase [NADPH] 1;
    Alternative:
    20-beta-hydroxysteroid dehydrogenase;1.1.1.197;15-hydroxyprostaglandin dehydrogenase [NADP+]);Prostaglandin 9-ketoreductase;NADPH-dependent carbonyl reductase 1;1.1.1.189;Prostaglandin-E(2) 9-reductase);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    277
    Sequence:
    50:
    MSSDRPVALV | TGANKGIGFA | IVRDLCRKFL | GDVVLTARDE | SRGHEAVKQL | 
    100:
    QTEGLSPRFH | QLDIDNPQSI | RALRDFLLQE | YGGLNVLVNN | AGIAFKVVDP | 
    150:
    TPFHIQAEVT | MKTNFFGTQD | VCKELLPIIK | PQGRVVNVSS | SVSLRALKSC | 
    200:
    SPELQQKFRS | ETITEEELVG | LMNKFIEDAK | KGVHAKEGWP | NSAYGVTKIG | 
    250:
    VTVLSRIYAR | KLNEERREDK | ILLNACCPGW | VRTDMAGPKA | TKSPEEGAET | 
    277:
    PVYLALLPPG | AEGPHGQFVQ | DKKVEPW
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    E10192p
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    Packing:
    96T
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    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    E10192r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    E10192b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    E10192m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    MSDS:
    Please sign in first.
    ELISA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    E10192h
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    Packing:
    96T
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    U10192m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    U10192r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    U10192h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    U10192b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    U10192p
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    P10192Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    P10192Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Polyclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Cat.:
    P10192Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Monoclonal Antibody for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1
    Protein for Rat Carbonyl reductase [NADPH] 1

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    References
    1. 1.
      "Cloning and expression of carbonyl reductase from rat testis."
      Wermuth B. , Maeder-Heinemann G. , Ernst E.
      Eur. J. Biochem.228:473-479(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
      strain: Sprague-Dawley.
      tissue: Testis.
    2. 2.
      "Identification of two closely related genes, inducible and noninducible carbonyl reductases in the rat ovary."
      Aoki H. , Okada T. , Mizutani T. , Numata Y. , Minegishi T. , Miyamoto K.
      Biochem. Biophys. Res. Commun.230:518-523(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Spleen.
    4. 4.
      Lubec G. , Diao W. , Afjehi-Sadat L. , Chen W.-Q.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 6-14; 17-24 AND 59-71;IDENTIFICATION BY MASS SPECTROMETRY
      strain: Sprague-Dawley.
      tissue: Hippocampus.
      tissue: Spinal cord.
    5. 5.
      "A novel 34 kDa glutathione-binding protein in mature rat ovary."
      Toft E. , Soederstroem M. , Ahlberg M.B. , DePierre J.W.
      Biochem. Biophys. Res. Commun.201:149-154(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 104-138
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